Mahindra project report Essay Example for Free

Mahindra project report Essay After concrete efforts of our Management, the students of Kohinoor Management School got this esteemed opportunity to have an Industrial visit to a prestigious company like Mahindra and Mahindra Ltd. We appreciate the efforts of the management of KMS MM for executing this successful Industrial trip. Introduction to Mahindra: Mahindra Mahindra Limited is the flagship company of the Mahindra Group, a multinational conglomerate based in Mumbai, India. The company was set up in 1945 in Ludhiana as Mahindra by brothers K. C. Mahindra and J.C. Mahindra. Mahindra Mahindra is a major automobile manufacturer of tractors, utility vehicles, passenger cars, pickups, commercial vehicles; its tractors are sold on six continents. It has acquired plants in China and the United Kingdom, and has three assembly plants in the USA. MM has a global presence and its products are exported to several countries. Its global subsidiaries  include Mahindra Europe Srl. based in Italy, Mahindra USA Inc., Mahindra South Africa and Mahindra (China) Tractor Co. Ltd. MM is one of the leading tractor brands in the world by volume. It is also the largest manufacturer of tractors in India with sustained market leadership of over 25 years. It designs, develops, manufactures, and markets tractors as well as farm implements. The Journey Begins†¦. We reached the Mahindra plant at Kandivali, Mumbai. We headed to the Conference room and were briefed about the Company by a presentation on the leadership and the entire group of MM followed by the Q A Session which lasted for an hour. The honors were done none other than Mr. Shirish Tawde, the Deputy General Manager (DGM) of the Company. Accompanying him were Mr. Kishor Sonawane (Manger Business Excellence), Rajendra Sawant (Sr. Manager Business Excellence), Mr. Mahesh Dalvi (Manager Business Excellence, Sector Sustainability). With such dignitaries explaining us the world of MM, we were just as grateful. This plant mainly deals in manufacturing of Tractors and Farm Equipments. The plant is one of the oldest manufacturing plants in the production of tractors in India. After decades in leading the tractor sector MM have diversified into the roots of farming and have positioned themselves in the Farm Sector. After being briefed through the introduction of MM plant, we were about to explore the India’s most Prestigious Companies. We were divided into 2 groups of 15 people so as to have individual attention . We visited 3 units of the plant right from examination of engine parts, assembling of engine and main manufacturing of tractors. They manufacture 2,00,000 tractors annually. The FES contributes 35% market share. Hands on approach to Production (where theory meets practical): Each Group was taken separately and explained functioning of the plant. A lot of theory is learnt is class regarding how the manufacturing units focus on Total Productivity, Total Quality, Zero Defect, etc†¦but by far this was the  first hands on experience on how does a Manufacturing unit or plant works. Here we are explained about how the assembly line manufacturing process works. This section of the plant deals with the installation of the main engine of the tractor. In this picture we are introduced to how the stations work in co-ordination to get optimum results. In the pictures below, the students are taken through a complete channel of stations on the assembly station and the supervisor explaining each of this complicated process. The lag or lead time is calculated and each one at every station tries to improve on it so as to reduce the time effect in assembling each engine. The units where tractors are manufactured in assembly lines follow Total Quality Management (TQM) and Total Productivity Management (TPM). Every sub-unit contributes to the production. They avoid material handling losses with pulleys and fork-lifts. All these techniques add value to the production. Indeed there is no surprise they improve their quality and reduce time with ever unit of production of tractor. Here, we are shown how the final tractors are put in place Students Opinion: Kohinoor Management School gave us the Golden Opportunity to visit the Mahindra and Mahindra plant at Kandivali. It was a great experience to know the organization internally. They are successful enough to balance between Business Excellence and Individual Dignity. Their main focus on farm tech prosperity is what like me a lot, as agriculture is the base of the Indian Economy. -Pratibha Shinde. Visit to the M M was an eye-opener. The journey unfolded various aspect of the tractor division. Starting from the nuts and bolts, the engine, to the massive structure which forms the backbone of the Indian farms and agricultural sector. The gains or the take away from the visit were splendid. The use of Japanese technology in the assembly line, the step by step process layout, the plan B; the vision of always staying ahead were the insights. Lots of management mantras were demonstrated and inculcated. A great learning and an honour to see the invasion of the GREAT INDIAN TRACTOR DIVISION. -Yogendra Joshi. It was my first Industrial visit to any manufacturing plant and enjoyed every bit of it. To be a part of such an esteemed organization and having a look through all their process was an intriguing experience after all. -Shraddha Salunke On behalf of all the Management and the students we take this opportunity to thank the entire team of Mahindra and Mahindra for providing us with the practical information and well as wonderful hospitality. We take moment to offer our greetings to the entire Mahindra and Mahindra team.

Drugs Affecting the Central Nervous System (CNS)

Drugs Affecting the Central Nervous System (CNS) Drugs acting in CNS were among the first to be discovered by primitive humans and are still the most widely used group of pharmacologic agents. In addition to their use in therapy, many drugs acting on the CNS are used without prescription to increase ones sense of well being. The mechanism by which various drugs act in the CNS have not been clearly understood. In last three decades, however, dramatic advances have been made in the methodology of CNS pharmacology. It is now possible to study the action of a drug on individual cells and even single ion channels with synapses. The information obtained from such studies is on the basis for several major developments in studies of the CNS. These are the classification of CNS acting drugs. In addition to many medical uses, drugs acting on the cns are using worldwide i.e. alcohol, nicotine, caffeine with various degrees of societal controls due to production of addiction or dysfunctional behaviours. We know that CNS acting agents mainly exert their effects by modulation of synaptic transmission of information between neurons. These actions alter the electrical exciteability of nerve cells by changing the movement of chemical ions across  nerve and neuron cell membrane. In general, these drugs ct on a receptor to directly or indirectly open or close ion channels in the cell membrane and thus make the nerve cell more exciteable with regard to its ability to send information. ION CHANNELS: The membrane of nerve cells contain two types of channels defined on the basis of the mechanism controlling their gating: voltage-gated and ligand-gated channels.Voltage gated channels see Table-1 are respond to changes in the membrane potential of the cell.In nerve cells, these channels are concentrated on the initial segment and the axon and are responsible for the fast action potential,which transmitthe signal from cell body to nerve terminal. There are many types of voltage-sensitive calcium and potassium channels on the cell body, dendrites and initial segment, which act on a much slower time scale and modulate the rate at which the neuron discharge. CHANNEL TYPE MODE OF TOXIN ACTION:  Tetrodotoxin VOLTAGE-GATED:  Blocks channel from outside MODE OF TOXIN ACTION:  Betrachotoxin VOLTAGE-GATED:  Slows inactivation MODE OF TOXIN ACTION:  Apamin VOLTAGE-GATED:  Blocks small Ca-activated K-channels MODE OF TOXIN ACTION:  Agatoxin VOLTAGE-GATED:  Blocks p-type channels MODE OF TOXIN ACTION:  Omega-conotoxin VOLTAGE-GATED:  Blocks n-type channels MODE OF TOXIN ACTION:  Charybdotoxin VOLTAGE-GATED:  Blocks big Ca-activated K-channels IDENTIFICATION OF CENTRAL NEUROTRANSMITTER: Because drug selectivity is based on the fact that different pathways use different transmitters, a primary goal of neuropharmacologists is to identify the transmitter in CNS pathways. Establishing that a chemical substance is a transmitter has been far more difficult for central synapses than for peripheral synapses. The following criteria have been established for transmitter identification: LOCALIZATION: Approaches prove that a suspected transmitter resides in the presynaptic terminal of the pathway uder study include biochemical analysis of regional concentrations of suspected transmitters and immunocutochemical techniques for enzymes and peptides. RELEASE: To determine whether the substance is released from a particular region, local collection of the extracellular fluid can sometimes be accomplished. In addition, slices of brain tissue can be electically or chemically stimulated in vitro and the released substances measured. To determine whether release is relevant to synaptic transmission, it is important to establish that the release is calcium-dependent. SYNAPTIC MIMICRY: Finally, application of the suspected substance should produce a response that mimics the action of the transmitter released by nerve stimulation. Furthermore, application of the selective antagonist should block the response. The excitatory neurotransmitter released from these cells is in most instances. The information is typically phasic and bursts of action potential. Microionophoresis, which permits highly localized drug administration, has been a valuable technique in assessing the action of suspected transmitter. Because of the complexity of the CNS, specific pharmacologic antagonism of a synaptic response provides a particular powerful technique for transmitter identification. DRUG CONCENTRATION AND INTESITY OF ITS EFFECTS: Intensity of pharmacological effect is given as, Intensity of effect= DRUGS ACTING UPON CNS: CAFFEINE: Caffeine and the chemically related xanthenes, theophylline and theobromine Decreases in the order given in their stimulatory action.They are over-the-counter drugs, used to block adenosine receptor as an antagonist. AMPHETAMINE: The stimulation caused by excessive release of norepinephrine from storage sites in the peripheral nervous system. It is not known whether the same action occurs in the CNS. Two other theories regarding for their action are that they are degraded slower than epinephrine or that they could act on serotonin receptor sites. NARCOTICS: Narcotic agents are potent and effective for the relief of severe pain. Analgesics are selective cns drug to reduce pain.Long term administration produces tolerance, pstchic and physical dependence. CENTRAL NERVOUS SYSTEM DEPRESSANTS AND STIMULANTS: CNS DEPRESSANTS: CNS depressants slows down normal brain functions. In higher doses, some CNS depressants can become general anesthetics. Tranquilizers and sedatives are example of CNS depressants. CNS depressants are based on two groups such as: CNS STIMULANTS: Stimulants increase alertness, attention and energy which are accompanied by increases in blood pressure rate and respiration. Stimulants were used to treat asthma and other respiratory problems, obesity, neurological disorder and a variety of other ailments. As their potential for abuse and addiction became apparent to wane. Now, stimulants are prescribed for treating only a few health conditions, include attention deficit hyperactivity disorder and depression that has not responded to other treatment. It is also used for short-term treatment of obesity and for patients of asthma. INTODUCTION TO SEDATIVE-HYPNOTIC: Interms of drugs, sedative refers to a substance that moderates the activity and excitement while inducing a calming effect, while hypnotic effect refers to a substance that causes drowsiness and facilitates the onset and maintenance of natural sleep. The term anxiolytic is sometimes applied to a sedative-hypnotic; however, be aware that many drugs especially the selective serotonin secretion reuptake inhibitors are useful as a chronic anxiolytic dug demonstrated by their efficacy in certain psychiatric disordres like generalized anxiety disorder. THERAPEUTIC EFFECTS OF SEDATIVE-HYPNOTICS: SEDATION: All drugs in this class produce sedation,, with relief of anxiety. Benzodiazepenes also exert anterograde amnesic effects (i.e the inhability to remember events occuring during the drug action ) at sedative doses. The amnesic action is a primary reason some benzodiazepenes ( i.e., midozam ) are commonly used for short duration invasive procedures. They donot provide pain relief however, and must be used in conjunction with analgesics. HYPNOSIS: Sedative-hypnotics promote sleep onset and increase the duration of sleep. All of the sedative-hypnotics will induce sleep if given in high enough dose. Rapid eye movement ( REM ) sleep stages are usually decreased at high doses. REM rebound can be detected following termination of sedative-hypnotics. ANESTHESIA: At high doses, sedative- hypnotic produce a loss of consciousness with amnesia at high level and a suppression of reflexes. Anesthsia can be produced by most barbiturates and some benzodiazepene, which is generally used frequently as a induction agent for general anesthesia. Only three, diazepam, midazolam and lorazepam are formulated I.V. ANTI-CONVULSANT AGENT: Most barbiturates and some benzodiazepene suppress seizures activity at high dose. However, often this occur along with marked sedation. Selective have anti-convulsant activity and can decrease the spread of epileptiform activity without CNS depression. Some are administered intravenously to treat status epilacticus. MUSCLE RELAXATION: Most sedative-hypnotics causes muscle relaxation at high doses. Diazepam is effective at sedative doses and is useful for treating specific spasticity state including cerebral palsy. TOLERANCE AND DEPENDENCE: TOLERANCE: Decreased responsiveness to a drug following repeated exposure commonly occurs with the continuous use of sedative-hypnotics. The mechanism of action of sedative-hypnotics are not well known. DEPENDENCE: Psychologicaaly dependence usually occurs wit h most of the sedative-hypnotics with leads to the compulsive use of these agents to reduce anxiety. Physical dependence is the development of withdrawal syndrome occurs when the drugs are discontinued. Withdrawal syndrome includes, tremors, hyper reflexia, and seizures. These symptoms occur most commonly with shorter acting drugs. EFECTS ON CNS WITH INCREASING DOSAGE: Calmness or drowsiness (sedation) Sleep (pharmacological hypnosis) Unconsciousness Coma Surgical anesthesia Fatal respiratory/ cardiac depression INTRODUCTION TO ANALGESICS: An analgesic also known as a painkiller is any member of the group of drugs used to relieve pain. Analgesic drugs act in various ways on the peripheral and central nervous system they include paracetamol and acetylaminophetol also known in the us as acetaaminophen, the NSAIDs such as the acetyl salicylic acid and opiods drugs such as morphine and opium. They are distinct from anesthesia who reversibly eliminate sensation. In choosing analgesics, the severity and response to the medication determines the pain ladder is originally developed in cancer-related pain is widely applied to find suitable drugs in a step wise manner. The choice is also determined by the type of pain, for neuropathic pain, traditional analgesics are less effective and there is often benefit from classes of drugs that are normally not considred analgesics such as tricyclic anti-depressants and anti-convulsants. WHAT IS PAIN ? Pain is physiological process that can be classified interms of its intensity ( mold, moderate, severe) its duration (acute, convulascent, chronic) its mechaism ( neurologic, nociceptive, physiologic) and its clinical context ( post surgical, malignancy) pain detection or nocicepter requires activation of specialized transducers called nociceptor, see Table-2, which are activating following thermal, mechanical or chemical tissue injury and initiate different transmission of action potential to the dorsal horn of spinal cord. Category:  Physiological Cause:  Brief exposure to a noxious stimulus Symptoms:  Rapid, yet brief pain perception Example:  Touching a pin or hot object Category:  Nociceptive Cause:  Somatic or visceral tissue injury with medication impacting on intact nervous system Symptoms:  Moderate to severe pain, described as crushing, stabbing, usually worsen after the first 24 hours Example:  Surgical pain, traumatic pain, sickel cell crisis Category:  Neuropathic Cause:  Damage of dysfunctional of peripheral nerves or CNS Symptoms:  Severe lancinating, burning or electrical shock like pain Example:  Neuropathy, chronic regional pain syndrome, postherpetic neuralgia Category:  Mixed Cause:  Combined somatic and nervous tissue injury Symptoms:  Combination of symptoms, soft tissue pain and radicular pain Example:  Low back pain, back surgery pain Analgesics are a class of drugs used to relief pain. The pain relief by analgesics occurs either by blocking pain signals or by interfering with the brain interpretation of the signalwithout producing anesthesia or loss of consciousness. There are basically two kinds of analgesics: KINDS OF ANALGESICS: It should be noted that some reference include aspirin and other non-steroidal anti inflammatory drugs (NSAIDs) in the class of analgesics because they have some analgesic properties. Aspirin and NSAIDs primarily have an anti-inflammatory affect, as opposed to being solely analgesic. NON-NARCOTIC ANALGESICS: Acetaminophen is the most commonly used over-the-counter, non-narcotic analgesic. Acetaminophen is a popular pain reliver because it is both effective for mild and moderate relief of pain and relatively inexpensive. It must be emphasized though that the safety of acetoaminophen is tied to proper use of the drug (use according to specific prescribed instructions). If acetoaminophen is not used according to the directions on the label, serious side effects and possible fatal consequences can occur. For example, taking more than 4000 mg/day or using it long term can increase the risk of liver damage. The risk of liver damage also increased by ingesting alcohol. Many people donot realize that acetoaminophen is found in more than 600 OTC. It can be found in combination with other active ingredients in many cold, sinus and cough medications. The commulative effect of acetaminophen must be considered if you are taking multiple drugs which contain acetaminophen. NARCOTIC ANALGESICS: There are two types of narcotic analgesics: The opiates (found in alkaloid, opium) The opioids (derivatives of opiates) Opiods are any medication which binds to opioid receptors in the CNS or gastrointestinal tract. There are four broad classes of opioids: Endogenous oopioids peptides (produced in the body: endorphins, dynorphins, enkephalins) Opium alkaloids (morphine, codeine, theibaine) Semi-synthetic opiods ( heroin, oxycodone, hydrocodone, dihydrocodeine, hydromorphone, oxymorphone) Fully synthetic opioids (pethidine, methadone, fentanyl, propoxyphene, buprenorphine) Opioids are used in medicine as strong analgesics, for relief of severe or chronic pain. There is no upper limit for the dosage of opioids used to achieve pain relief, but the dose must be increased gradually to allow for the development of tolerance to adverse effects ( for eg. Respiratory depression). According to emedicine: some people with intense pain get such high doses would be fatal if taken by someone who was not suffering from pain. PHARMACOLOGY OF SYSTEMIC ANALGESICS: Systemic administration of analgesic drugs is still the most widely used method for providing pain relief in acute painful situations. Opioids may be selected on the basis of their physicochemical characteristics and their diffusion index to the brain. But in clinical practice, their very steep concentration-analgesic effect relationship remains a critical aspect of opioid therapy. Thus, small fluctuations in plasma concentrations of opioids may lead to profound fluctuations in analgesic effect when their plasma and effect-site concentrations are near the minimum effective analgesic concentration (MEAC). Combining drugs acting on different mechanisms of nociceptive modulation offers benefits from additive/synergistic effects and will decrease the incidence of their adverse effects. Evidence-based reviews showed that effective pain relief using non-opioid analgesics relied on paracetamol supplemented with non-steroidal anti-inflammatory drugs (NSAIDs). The role of COX-2 selective inhi bitors (CSIs) in acute pain relief still requires further evaluation. NSAIDs, CSIs and paracetamol share the property of morphine sparing in situations of severe (post-operative) pain. CSIs may be beneficial in patients in whom post-operative bleeding is a major surgical risk as the effects of NSAIDs on coagulation may last for days. Finally, low-dose ketamine infusions remain a worthwhile addition to opioid therapy. Analgesic concentrations of ketamine are 1/5th to 1/10th the anaesthetic concentration and exert significant inhibition on N-methyl-d-aspartate (NMDA) receptor activation. There have been debates over the additine potential of opioids vs. the benefits of their analgesic properties for treating non-malignant chronic pain such as chronic arthritis. Some experts believe opioiods can be taken for years without addiction or toxic side effects. The enhanced quality of life which opioids may provide the patient must considered. Common SIDE EFFECTS and ADVERSE REACTION: Nausea Vomiting Drowsiness Dry mouth Miosis (contraction of pupil) Urinary retention Constipation or fecal impaction Orthostatic hypotension Less common SIDE EFFECTS and ADVERSE REACTION: Confusion Hallucinaation Hives Itch Bradycardia Hypothermia Raised intracranial pressure Tachycardia Flushing Muscle rigidity Most severe SIDE EFFECTS and ADVERSE REACTION: Respiratory depression Fatal overdose INTRODUCTION TO ANTI-SEIZURES: After stroke, epilepsy is the second common disorder of CNS affecting about 1% of the population worldwide. Most (80%+) cases can be well controlled with anti-seizures drugs. However, that leaves many characterized by periods of abnormal firing of CNS neurons and can be caused by many neurological conditions (i.e. tumors, injury, infection). In some cases, there is also agenetic predisposition to epilepsy. Anti-seizures medication were originally designed to help people who have epilepsy, but the nerve-calming quality of some of these drugs can also help quiet the burning, stabbing or shooting pain often caused by nerve damage. Nerve damage (neuropathy) can be caused by many factors, including: DIABETES: High blood sugar levels, common in diabetes, can damage the nerves throughout the body, but the first symptomatically is numbnessand pain in the hands and feet. SHINGLES: Anyone who has had chicken pox is at risk of shingles a rash of blisters that can be painful or itchy. A condition called postherpetic neuralgia occurs if shingles pain persists after the rash disappears. Because the risk of shingles increases with age, evryone everyone everyone age 60 or older should receive the zoster vaccine which can help prevent this painful condition. CHEMOTHERAPY: Some chemotherapy drugs can damage nerves causing pain and numbness that typically begins in the tip of toes and fingers. HERNIATED DISK: Nerve damage can occur if a herniated in your spine squeezes a nerve passing through your vertebrae too tightly. INHERITED NEUROPATHIES: Some neuropathies are passed on genetically and affects different nerves, depending upon the type of disorder. The most common hereditary neuropathy is Charcot-Marie-Tooth disease which affects motor and sensory nerves. MECHANISMS OF ANTI-SEIZURE DRUGS: Exact mechanism of anti-seizues drugs are not well understood but tese medications appear to interfere with the over react transmission of pain signals sent from damaged nerves. Some anti-seizures work particularly well for certain conditions. Carbamazepine is prescribed for trigeminal neurolgia, a condition that causes facial painn appears as electrical shocks. It is important note that FDA has issued a warning that all anti-seizures associated with a slight increased risk of suicidal thoughts or actions. Talk to your doctor if you are experiencing feeling of depression or suicidal thoughts. GABAPENTIN: Used with other epilepsy drugs to treat partial and some generalized seizures. Few lasting side effects. During the first week of treatment, a person may experience tiredness and dizziness. PHENYTOIN: Controls partial seizures and generalized tonic-clonic seizure. Also can be given by intravenously in the hospital to rapid control active seizures. Side effects include dizziness, fatigue, acne, slurred speech, rash, and increase hair. Over the long term the drug can cause bone thinning. VALPROIC ACID: Used to treat partial, absence and generalized tonic-clonic seizures. Common side effects include dizziness, nausea, vomiting, tremor, hair loss, reduced attention, depression in adults, irritability in children, a decrease in thinking speed. Over the long term, the drug can cause bone thinning, swelling of the ankles, liver damage, decreased platelets. INTRODUCTION TO ANTI-PSYCHOTICS: A person who is psychic out of touch with the reality. People with psychosis may hear voices or have strange and illogical ideas for eg, thinking that others can hear their thought or are trying to harm them or they are president o f us or some famous person. They may get excited or angry with no apparent reason, or spend lots of time by themselves or in bed, sleeping during the day and awake at night. The person may neglect appearance, not bathing or changing clothes, hard to talk to- barely talking or saying things that make non-sense. They often are initially unaware that their condition is an illness. These kinds of behavior are symptoms of a psychotic illness such as schizophrenia. Anti-psychotic drugs reduces these symptoms. These medications cannot cure the disease but they can take away many of the symptoms or make them mild. In some cases, they can shorten the course of episode of illness well. There are number of anti-psychotic medications available. These medications affect the neurotransmitter that allow communication between nerve cells. One such neurotransmitter, dopamine, is thought to be relevant to schizophrenia symptoms. All thes e medications have some effect for schizophrenia. The main differences are in their potency that is the dosage prescribed to produce therapeutic effect. Some people may think that thehigher doses of medication prescribed the more serious the illness but this is not always true. The 1990s saw the development of several new drugs for schizophrenia called atypical antipsychotics because they have fewer side effects than the older drugs, today they are often called and used as afirst line of treatment. The first atypical antipsychotic drug was introduces in 1990. In clinical trials, these medications were found to be more effective than conventional or typical Antipsychotic drugs in individuals with treatment-resistant schizophrenia, that is not responded to other drugs and the risk of tardive dyskinesia ( a movement disorder was lower). However because of the potential side effects of serious blood disorder -agranulocytosis, white blood cells loss that fight infection. Patient who are on clozapine must have a blood test on every 1 or 2 weeks. The inconvenience and cost of blood tests and the medication itself have made maintenance for adults for many people. Several other atypical antipsychotics have been developed since clozapine was introduced. INDICATIONS OF ANTI-PSYCHOTIC DRUGS: Common conditions with which antipsychotics might be used include schizophrenia, bipolar disorder and delusional disorder. Antipsychotics might also be used to counter psychosis associated with a wide range of other diagnoses, such as psychotic depression. However, not all symptoms require heavy medication and hallucinations and delusions should only be treated if they distress the patient or produce dangerous behaviors. For non-psychotic disorders: In addition, antipsychotics are increasingly used to treat non-psychotic disorders. For example, they are sometimes used off-label to manage aspects of Tourette syndrome or autism spectrum disorders. They have multiple off-label uses as an augmentation agent (i.e. in addition to another medication), for example in treatment-resistant depression essive, anti-impulsive, anti-suicidal and hypnotic (sleep) medications. Antipsychotics have also been increasingly used off-label in cases of dementia in older people, and for various disorders and difficulties in children and teenagers. A survey of children with pervasive developmental disorder found that 16.5% were taking an antipsychotic drug, most commonly to alleviate mood and behavioral disturbances characterized by irritability, aggression, and agitation. Recently, risperidone was approved by the US FDA for the treatment of irritability in children and adolescents with autism. Antipsychotics are sometimes used as part of compulsory treatment via inpatient (hospital) commitment or outpatient commitment. This may involve various methods to persuade a person to take the medication, or actual physical force. Administration may rely on an injectable form of the drug rather than tablets. The injection may be of a long-lasting type known as a depot injection, usually applied at the top of the buttocks. Those that are available in injectable form are haloperidol, olanzapine, and ziprasidone while those available as depot are haloperidol, flupenthixol, clopenthixol, and risperidone. Antipsychotics are among the biggest selling and most profitable of all drugs, generating $22 billion in global sales in 2008. By 2003 in the US, an estimated 3.21 million patients received antipsychotics, worth an estimated $2.82 billion. Over 2/3 of prescriptions were for the newer more expensive atypicals, each costing on average $164 compared to $40 for the older types. By 2008, sales in the US reached $14.6 billion, the biggest selling drugs in the US by therapeutic class. The number of prescriptions for children and adolescents doubled to 4.4 million between 2003 and 2006, in part because of increases in diagnoses of bipolar disorder. Due to the chronic nature of the treated disorders, antipsychotic medications, once started, are seldom discontinued, and the aim of the treatment is often to gradually reduce dosage to a minimum safe maintenance dose that is enough to control the symptoms. Only when the side-effects have become too severe and/or a patient have been symptom-free for a long periods of discontinuation carefully attempted. MULTIPLE MEDICATIONS: Antipsychotic medications can produce unwanted effects when taken with other medications therefore, doctor should be told about all the medications being taken including over -the-counter medications and vitamin, mineral, and herbal supplements and the extent of alcohol use. Some antipsychotic interfere with anti-hypertensive drugs (taking for high blood pressure), anticonvulsants (taken for epilepsy) and medicine used for parkinsons disease. Other anti-psychotic add to the effect of a alcohol and other CNS depressants such as anti-histamines, barbiturates, anti-depressants, some sleeping and pain medications and narcotics. OTHER EFFECTS: Long term treatment of schizophrenia with one of the older, or, conventional antipsychotics may cause to develop tardiye dyskinesia. Tardiye dyskinesia is a condition characterized by involuntary movements, most often around the mouth. It may range from mild to severe. In some people, it cannot be reversed, while others recoverd partially or completely. Tardiye dyskinesia is sometimes in people with schizophrenia who have never been treated with an antipsychotic medications is called spontaneous dyskinesia however, it is most often seen after long term treatment with older antipsychotic medications. The risk has been reduced with newer atypical medications. There is a higher incidence in women, and the risk increases with the age. The possible risks of long-term treatment with with an anti-psychotic medications must be weighed against the benefit in each case. The risk of TD is 5% per year with older medications. It is less with newer medications. PSYCHOTIC DISORDER CAUSES: Functional causes of psychosis include the following: Drug abuse amphetamines, cocaine, marijuana, http://en.wikipedia.org/wiki/Alcoholismalcohol among others. Brain damage Schizophrenia, schizophreniform disorder, schizoaffective disorder, brief psychotic disorder Bipolar disorder (manic depression) Severe clinical depression Severe psychosocial stress Sleep deprivation. Some traumatic events. DOSAGES AND SIDE EFFECTS: Some medications are very potent and prescribed in low doses, others are not as potent and higher doses are prescribed. Most side effects of antipsychotic drugs are mild. Many common ones lessens or disappear after the first week of treatment. these includes drowsiness, rapid heart beat and dizziness when posture changes. Some people may gain weight while taking medications and need to pay extra attention to diet or exercise to control their weight. All anti-psychotic drugs tend to block D2- receptors in the dopamine pathways of the brain. This means that dopamine released in these pathways has less effect. Excess release of dopamine in the mesolimbic pathway has been linked to psychotic experiences. It is the blockade of dopamine receptors in the pathway that is thought to control psychotic experience. Typical antipsychotic are not particularly selective and also block dopamine receptors in the mesolimbic pathway, tuberoinfundibular pathway and the nigrostriatal pathway. Blocking D2- receptor s in these pathway is thought to produce some of the unwanted effects which typical antipsychotics produce. LITHIUM, MOOD STABILIZING DRUGS, AND OTHER TREATMENT FOR BIPOLAR DISORDER: Bipolar disorder once known as manic-depressive illness, was conceived of as a psychotic disorder distinct from schizophrenia at the end of the 19th century. Before that both of these disorders were considered part of a continuum. It is ironic that the weight of the evidence today is that there is profound overlap in these disorders. This is not to say that there are no pathophysiology important difference or that some drugs treatment are differentially effective in these disorders. According to DSM, they are separate disease entities while research continues to define the dimensions of these illnesses and their genetic and other biological markers. TYPES OF BIPOLAR DISORDER There are several types of bipolar disorder. Each type is identified by the pattern of episodes of mania and depression. The treatment that is best for you may differ depending on the type of bipolar disorder you have. Your doctor will look carefully to determine where your symptoms fit. Bipolar I Disorder (mania and depression) Bipolar I disorder is the classic form of the illness, as well as the most severe type of bipolar disorder. It is characterized by at least one manic episode or mixed episode. The vast majority o

Crawling Inside the Mind of Shakespeares Hamlet Essay -- GCSE Coursew

Crawling Inside the Mind of Hamlet  Ã‚  Ã‚  Ã‚  Ã‚   Much of the dramatic action of Shakespeare’s tragedy, Hamlet is within the head of the main character, Hamlet.  Ã‚   His wordplay represents the amazing, contradictory, unsettled, mocking, nature of his mind, as it is torn by disappointment and positive love, as Hamlet seeks both acceptance and punishment, action and stillness, and wishes for consummation and annihilation. He can be abruptly silent or vicious; he is capable of wild laughter and tears, and also polite badinage. One of the first things which a reader learns about Hamlet is that he uses words with startling agility. He plays on words that sound alike, or nearly alike: King. But now, my cousin Hamlet, and my son-- Ham. A little more than kin, and less than kind. King. How is it that the clouds still hang on you? Ham. Not so, my lord; I am too much in the sun. (I.ii.64-67) The king withdraws from this exchange, and his mother begins more lovingly, on a different tack. But still Hamlet takes words that others have used and returns them changed or challenged: â€Å"Ay, madam, it is common./. . . Seems, madam? Nay, it is. I know not 'seems'† (I.ii.74-76).   Although the prince is speaking in public, he uses verbal rhetorical devices most critics in Shakespeare's day would consider unseemly. Hamlet's first words are rhetorically complicated, and also challenging and puzzling. Does he pretend to be flippant or boorish in order to keep his thoughts to himself, or to contain his pain? Or does he express rational criticism in savagely sarcastic comments spoken only to himself? Or is the energy of his mind such that he thinks and speaks with instinctive ambiguity? Words are restless within his mind, changing meaning, sh... ...espeare, William. 1985. Hamlet. The New Cambridge Shakespeare edn, edited by Philip Edwards. Cambridge: Cambridge University Press. Vickers, Brian. 1993. Appropriating Shakespeare: Contemporary Critical Quarrels. New Haven and London: Yale University Press. Watson, Robert N. 1990. 'Giving up the Ghost in a World of Decay: Hamlet, Revenge and Denial.' Renaissance Drama 21:199-223. Wright, George T. 1981. 'Hendiadys and Hamlet.' PMLA 96:168-193. Shakespeare, William. The Tradegy of Hamlet Prince of Denmark.   New York: Washington Square Press, 1992 Weiten, Wayne. Psychology: Themes and Variations, Fourth Editon. Boston: Brooks/Cole Publishing Co., 1998 Watson, Robert N. 1990. 'Giving up the Ghost in a World of Decay: Hamlet, Revenge and Denial.' Renaissance Drama 21:199-223. Wright, George T. 1981. 'Hendiadys and Hamlet.' PMLA 96:168-193.

Good Use - The Customer is Always Right Essay -- Teaching Writing Educ

Good Use - The Customer is Always Right Does "I respectfully submit my resignation," convey the same meaning as, "I quit?" Certainly the tone of voice is different, but do these two phrases say the same thing? Which one is correct? In answering these questions we are making decisions about what constitutes good use in writing techniques. According to Orwell's Advice for Writing, one should, "Never use a long word where a short one will do." Following this line of thinking one would logically conclude that "I quit," a phrase of only five characters in length, is by far the better choice when comparing it to the thirty-two character alternative, "I respectfully submit my resignation." However, there may just be a bit more to proper usage in writing than choosing between longer and shorter words/phrases of the same meaning. In fact, the most important aspect of usage may just be the audience for which the writing is intended. (in other words, it's not the size that counts, it's whose using it!) For example, J. D. Thomas point s out that in technical writing, "Efficient communication depends upon a 'middle' range..." or writing that will be utilized by people with varied educational/technical backgrounds. Technicians use jargon that may not be understood by an otherwise well educated person. Therefore, if a technician wants to write a paper explaining some revolutionary way of manufacturing to a potential investor, she's going to have to adjust her writing to suit her audience so as to successfully convey her message. However, the same paper would have to be amended to include specific, object-oriented terminology if it were targeted towards the technician's peers. Another important aspect of good usage, according to T. Cliffo... ... audience is the determining factor of good use. The two phrases mentioned earlier, "I quit," and "I respectfully submit my resignation," illustrate the power the audience has in writing. Without knowing for whom the phrases are intended, the author can't make a decision between the two. "I quit," is short and to the point, but who is the writer talking to? Will the abrupt nature of the phrase cause tension or will the audience simply ignore it as insignificant babble? If it's an employer that she is expecting a good reference from, perhaps, "I respectfully submit my resignation," is the way to go. On the other hand, if shock value is the intent of the writer, an entire realm of discontinued-employment phrases may become appropriate. Metaphorically speaking, the audience is the customer in the department store of writing styles, and the customer is always right.

Mariah Carey :: essays research papers

Mariah Carey, the biggest-selling female recording artist of the 1990's was born and raised in New York by her mother, a former opera singer with the New York City Opera and a vocal coach, Mariah Carey began singing at age four. By the time she was in junior high school, she had begun to write songs. After her high school graduation, she got her fist big break, singing backup for Brenda K. Starr, a break that led to her signing with Columbia Records. And now Mariah is not only a singer, but also a writer and producer. Mariah Carey has had more #1 singles than any female artist, surpassing both the Supremes (12) and Madonna (11), and more #1's than any currently active recording artist. She has had more #1 singles (14) than any artist during the 1990's and seen more singles (3) debut at #1 than any artist in history. With more #1 albums (4) than any female artist in the 1990's Mariah was the first female artist to see two of her albums (Music Box and Daydream) reach the 10 million mark in sales and is the only female artist to have eight albums certified triple-platinum or better (in Mariah's case, her entire album catalog has achieved RIAA multi-platinum status). Mariah's 1990 eponymous debut album launched an unparalleled unbroken string of successes. Mariah Carey has sold more than 12 million albums worldwide, was certified 8x RIAA-platinum, and yielded a record-setting four consecutive #1 singles: "Vision of Love," "Love Takes Time," "Someday," and "I Don't Wanna Cry." The title track of 1992's quadruple-platinum Emotions generated her fifth consecutive #1 single, placing Mariah Carey in the Top Ten All-Time achievers of Most Consecutive #1 Hits. Emotions earned Mariah two Grammy nominations ("Best Pop Vocal, Female" and, with Walter Afanasieff, "Best Producer") and an American Music Award ("Favorite Female Artist, Soul/ R&B"). On March 17, 1992, Mariah appeared on MTV Unplugged, leading to the release of Mariah's sixth #1 single ("I'll Be There") as well as an EP which has been certified triple platinum in the U.S. and has sold more than five million copies worldwide. In 1993, Mariah released Music Box, an album which as sold more than 24 million copies worldwide, has been certified ten times RIAA platinum, and generated her seventh and eighth #1 singles "Dreamlover" and "Hero" as well as the Top 10 hit "Without You." Mariah followed up with her holiday album, Merry Christmas, which sold eight million copies worldwide shortly after its release in November 1994 and has been certified quadruple platinum by the RIAA.

American Literature: Pursuit of Happiness

Caitlyn Parker February 21, 2013 American Literature Essay #1 Pursuit of Happiness Comes in Many Ways In Ron Carlson’s â€Å"The Ordinary Son. † Reed discovers that what he might want in life is different than how his family lives. Reed’s family isn’t your typical scenario. His family is a â€Å"famous family,† a group of geniuses not known by their family’s last name but by each individual. The children even called their parents by their first names. They all had their own names, they were known by who they are not by the traditional way of saying, â€Å"Oh they are the Landers family. Geniuses lived not in a typical way of life. They were so focused on making the next big thing, that they never even spent family time together. Their house wasn’t full of fancy decorations, but actually quiet empty. They didn’t even have a dinner table. Geniuses weren’t social lights either, they never had people come over; they didnâ₠¬â„¢t keep up with all the tech savvy stuff either. They had no television or telephone. It was a genius household and it wasn’t to be diminished by electronic gismos. Reed accepted the way of life as a genius family.He realized that living without a telephone or refrigerator was natural for him. Didn’t even have a car. He was used to not living like society. He accepted this way of life, so simplistic and empty. He noticed that how they lived was very different than other people’s lives. He learned that society mostly was settled around two things: television and soft foods with tons of sugar. Living this way meant you didn’t sweat the small stuff, but to live for the work they do, not for things. They don’t need anything in life, just their brains full of ideas.Being in a household of geniuses is hard for Reed because he wasn’t like the rest of his family; he’s the odd one out. He didn’t spend his life trying to show off his talents or be an overachiever like his siblings. He would congratulate them and their successes but lived his life in the shadows, behind the fame. At the age of seventeen Reed discovered that the genius gene had skipped him and that at least he was smart but not going to be a genius. He was free. He felt more alive than ever. He figured that now he could do whatever he wanted, he had no obligations.These were the days for big change, to start his life the way he wanted too. He started by getting a job doing landscaping and general cleanup maintenance at a motel. He even bought a car. He began to alienate they ways of how he was raised. Reed began to live like society. He felt he was indifferent and wanted to learn from his peers. He had a friend, named Jeff who educated him on the larger things in life, like the sex department. He finally felt something to live for. He wanted to experience something so foreign to him and understand it. Reed was satisfied working a job and not takin g the high road in life.He worked hard and was making money. He didn’t weigh the little things; he just went with the flow. He didn’t need to live in the fast lane he was happy with a sweaty back and a pocketful of cash. He felt as if he was a genius in his own way. Working at the motel allowed him to start having a little life. He learned new skills and liked being able to stand up on his two feet without his family’s lights shining down on him. Reed was immersing himself in the real world. In Lorrie Moore’s â€Å"Community Life. † Olena wanted to be an English teacher and teach literature but she failed to graduate the study of it.She then transferred to library school where she was taught how to take care of books. She learned to read at a young age and loved to read. Olena learned to speak English and was taught to blend into the community at a young age. Every Saturday she would go to the library to read. She loved to go to the library, she fe lt as if she could do whatever she wanted. She became very fond of the librarian. Olena valued her mother and thanked her for teaching her English. Her parent’s wanted to give her an American life but Olena was left all alone due to a car accident when her parents died.Olena wished to start over, to be someone living in the world, hiding behind books and carefully learning voice. She missed her mother the most. The only thing to cope her pain was to work in a library surrounded by books, she loved to read and being around something you love helps her stay sane. Olena struggles with being social and brave. She likes to hide and not associate herself to the outside world. She likes libraries because there’s no who’s or whys just where is it. It’s an easy solution to escape the world around her. Olena seems very to herself, and doesn’t want to live her life like an American.She’s very stubborn when it comes to going out and living her life, she rather stay home and be isolated from the world. This makes her relationship suffer. Her partner, Nick tries to push her to connect to the community and go to events but she just argues and thinks these people are too glad-handing people who never really spoke to you but at you about their life stories. She could care less and didn’t want to associate with them. Olena lived differently than the society she began to be afraid of going out. She knew that she was a foreigner and a fool and she didn’t want to be part of it.Everything about the community was her enemy. She had become a rapist and strived to think something was wrong with her. This was a huge obstacle for her to overcome. She went through hysteria and spent her life in crisis. She hated America and tried to find herself throughout the entire process. â€Å"She was alone as a book, alone as a desk, alone as a library, alone as a pencil, alone as a catalog, alone as a number, alone as a notepad. † She had to lift herself from her loneliness to find her happiness. To be one with her parents again, searching to find herself.What is your definition of happiness? That is a good question, happiness comes in so many ways from small little gestures or an old friend saying, â€Å"You’re beautiful today. † Happiness is a word that associates with your surroundings. You would probably be happier if you just bought at new car rather than being hit by one. Your emotions play a lot into how you are feeling. You can feel happier when you see someone else smile because it makes you smile. For me, my happiness comes mostly from my family. With out my family I wouldn’t be who I am today.I’ve been through a lot of struggles while growing up and having to face problems at a young age made me become more independent on my own and stronger to face life’s hardships. When I was ten I had to live without a mother, this was very hard since she was my rock and I leaned u pon her for my every need. It was an adjustment to have to move on with my life and stay close to my older sister for guidance. Without my sister I don’t know how I would have been able to cope and succeed in my journey into adulthood. Ever since I was three years old I have loved to ice skate, skating is my escape from society it lets me free my mind.Whenever I’m down, I just think of skating and it makes me feel better. I love to skate and how it makes me feel free from anything, like I can do anything. Free as a bird. I value the little things in life, even though I never came from a rich family I have always never been forgotten. It’s great to have a few people love you tremendously rather than having no one there to support you. My dad has been a huge influence in my life because he has always been there for me, he would do anything for me and it’s great to know you have someone to count on.He has taught me so much and gave me his artist talents as w ell. Since I was little I have loved to draw, being creative is my section nature. I can do it in my sleep. I’m very passionate about being artistic; through generations my whole family has some kind of artistic ability. My grandfather was a painter, photographer, my grandmother knitted and sewed like a seamstress, my dad was an illustrator, drawer, my mom was a watercolor artist, and my aunt was a graphic designer, printmaker. It’s in my blood to be talented in the arts.I have always been passionate when it comes to making something beautiful and done from the hand. Life seems so much easier when you can make something from your heart. You can never buy something so eternally special. Being surrounded by loving people is a huge inspiration because they are your support group and when you feel down you just look to these people and they will always motivate you and push you in the direction you want to go in. In the future I hope to see myself becoming a designer.I lov e the thought of me opening up my own brand and starting a clothing line. I have always thought of myself becoming famous someday. My goals for myself is to finish school with honors and graduating with a degree in Graphic Design then continuing to complete my associates in Interior Design. Then after college start to work for a magazine or firm to get some experience and do logos, websites, etc. I think to maintain my happiness I just need to keep skating and don’t settle for a day job.I want to schedule my own hours and do work that will be something I enjoy rather than sitting at a desk all day being miserable. I also have always wanted to travel the world to get inspiration and if I follow my dreams, happiness will stay with me till I past. My purpose of life is to have fun and fulfill my wishes, if I don’t I will regret my life choices and be miserable for the rest of my life. If I keep up the hard work, my life will be complete and I will feel satisfied. Happines s is the way of life if your not happy then your not making your life have a purpose.Being able to use my imagination helps me cope with society, now a days everything is digitalized and electronic that my mind wants to explode. For me, I always have to step away from the computer and relax my mind. I love to do yoga and mediate it helps me become one with my body and it’s a reliever of stress. I also keep a journal to jot down notes or ideas that I might come across at random times. It helps me stay true to myself and when I’m having a bad day I just look in it and re-read silly things I wrote and it makes me feel better. I always feel happy when I’m being silly and just being myself.

Of Mice and Men: Euthanasia

Death is one of the things humans have to understand in order to be able to live through life. Being born, growing up, learning to survive, and earning a living, these are all the milestones into becoming a statistic. Like dying, mercy is a fortunate circumstance that a person has in any situation towards a variety of offenders. Some say that mercy is a blessing resulting from a divine favor. In the story, â€Å"Of Mice and Men† by John Steinbeck, Lennie was euthanized by George, Lennie’s caretaker/ friend.I believe that George, as a friend, only killed Lennie in grand admiration of Lennie’s already ill-fated continuance, like Candy’s dog. In the world of â€Å"Of Mice and Men†, Candy’s dog represents the fate awaiting anyone who has outlived his or her purpose. Quotes from Carlson, a ranch-hand, reveals this saying, â€Å"†Whyn't you get Candy to shoot his old dog and give him one of the pups to raise up? †, â€Å"I can smell t hat dog a mile away. †, â€Å"Got no teeth, damn near blind, can't eat. Candy feeds him milk. He can't chew nothing else†, and â€Å"He’s all stiff with rheumatism.He ain’t no good to you, Candy. An’ he ain’t no good to himself. † After this scene, Candy finally lets Carlson euthanize his dog. Both Lennie and Candy's dog would suffer if they lived. Candy's dog relates to the reason why Lennie was killed by George. Candy’s dog wasn't in good health and Lennie killed Curly's wife and would be in trouble with the law. Although Carlson promises to kill the dog painlessly, his insistence that the old animal must die supports a cruel natural law that the strong will dispose of the weak.Afterwards, Candy has regrets about the ordeal, and wishes he would have killed the dog himself instead. Like how Candy’s dog was euthanized, Lennie also was. He was killed with far greater compassion though. George loves his friend Lennie, whom he has looked after faithfully, and he doesn't want Lennie to die horribly. He euthanized him out of love, therefore he is justified. Since Lennie unwittingly killed Curley's wife, George knows that there is no way to save him now. Even if they do escape, Lennie will never be safe because he doesn't know how to avoid getting into trouble.Furthermore, if Curley gets his hands on Lennie, he will make his revenge be slow, terrifying, and painful. Therefore, George knows that the only way to protect Lennie is to shoot him. Lennie’s puppy is one of several symbols that also represent the victory of the strong over the weak. Lennie kills the puppy accidentally, as he has killed many mice before, by virtue of his failure to recognize his own strength. When Curley's wife screamed, he didn't know how to make her stop, except by force. Evidence supports that George must save his friend by mercifully killing him.†Of Mice and Men† reflects upon many situations of mercy in man y varieties. In this manner George is a divine favor over Lennie’s life bestowed upon him by Aunt Clara. As Lennie’s blessing, George had the god given right to distribute mercy upon his â€Å"other-half† in unfortunate circumstances. For this reason, Carlson and Curley represent the harsh conditions of a distinctly real world, a world in which the weak will always be vanquished by the strong and in which the rare, delicate bond between friends is not appropriately mourned because it is not understood. Of Mice and Men: Euthanasia Death is one of the things humans have to understand in order to be able to live through life. Being born, growing up, learning to survive, and earning a living, these are all the milestones into becoming a statistic. Like dying, mercy is a fortunate circumstance that a person has in any situation towards a variety of offenders. Some say that mercy is a blessing resulting from a divine favor. In the story, â€Å"Of Mice and Men† by John Steinbeck, Lennie was euthanized by George, Lennie’s caretaker/ friend.I believe that George, as a friend, only killed Lennie in grand admiration of Lennie’s already ill-fated continuance, like Candy’s dog. In the world of â€Å"Of Mice and Men†, Candy’s dog represents the fate awaiting anyone who has outlived his or her purpose. Quotes from Carlson, a ranch-hand, reveals this saying, â€Å"†Whyn't you get Candy to shoot his old dog and give him one of the pups to raise up? †, â€Å"I can smell t hat dog a mile away. †, â€Å"Got no teeth, damn near blind, can't eat. Candy feeds him milk. He can't chew nothing else†, and â€Å"He’s all stiff with rheumatism.He ain’t no good to you, Candy. An’ he ain’t no good to himself. † After this scene, Candy finally lets Carlson euthanize his dog. Both Lennie and Candy's dog would suffer if they lived. Candy's dog relates to the reason why Lennie was killed by George. Candy’s dog wasn't in good health and Lennie killed Curly's wife and would be in trouble with the law. Although Carlson promises to kill the dog painlessly, his insistence that the old animal must die supports a cruel natural law that the strong will dispose of the weak.Afterwards, Candy has regrets about the ordeal, and wishes he would have killed the dog himself instead. Like how Candy’s dog was euthanized, Lennie also was. He was killed with far greater compassion though. George loves his friend Lennie, whom he has looked after faithfully, and he doesn't want Lennie to die horribly. He euthanized him out of love, therefore he is justified. Since Lennie unwittingly killed Curley's wife, George knows that there is no way to save him now. Even if they do escape, Lennie will never be safe because he doesn't know how to avoid getting into trouble.Furthermore, if Curley gets his hands on Lennie, he will make his revenge be slow, terrifying, and painful. Therefore, George knows that the only way to protect Lennie is to shoot him. Lennie’s puppy is one of several symbols that also represent the victory of the strong over the weak. Lennie kills the puppy accidentally, as he has killed many mice before, by virtue of his failure to recognize his own strength. When Curley's wife screamed, he didn't know how to make her stop, except by force. Evidence supports that George must save his friend by mercifully killing him.†Of Mice and Men† reflects upon many situations of mercy in man y varieties. In this manner George is a divine favor over Lennie’s life bestowed upon him by Aunt Clara. As Lennie’s blessing, George had the god given right to distribute mercy upon his â€Å"other-half† in unfortunate circumstances. For this reason, Carlson and Curley represent the harsh conditions of a distinctly real world, a world in which the weak will always be vanquished by the strong and in which the rare, delicate bond between friends is not appropriately mourned because it is not understood.